The Collaborative Ocular Tuberculosis Study (COTS) Consensus (CON) Group Meeting Proceedings
Rupesh Agrawal, Ilaria Testi, Sarakshi Mahajan, Yew Sen Yuen, Aniruddha Agarwal, Andrés Rousselot, Dhananjay Raje, Dinesh Visva Gunasekeran, Onn Min Kon, Talin Barisani‐Asenbauer, John H. Kempen, Amod Gupta, Douglas A. Jabs, Justine R. Smith, Bahram Bodaghi, Manfred Zierhut, Marc D. de Smet, Peter Mc Cluskey, Mamta Agarwal, Manisha Agarwal, Kanika Aggarwal, Mukesh Agrawal, Hassan Al-Dhibi, Sofia Androudi, Fatma Asyari, Manohar Babu Balasundaram, Kalpana Babu Murthy, Edoardo Baglivo, Alay Banker, Reema Bansal, Soumyava Basu, Digamber Behera, Jyotirmay Biswas, Ester Carreño, Laure Caspers, Soon‐Phaik Chee, Romi Chhabra, Luca Cimino, Luz Elena Concha del Río, Emmett T. Cunningham, André Luiz Land Curi, Dipankar Das, Ekaterina V. Denisova, Alastair K. Denniston, Marie-Hélène Errera, Alejandro Fonollosa, Amala George, Debra A. Goldstein, Yan Guex Crosier, Avinash Gurbaxani, Alessandro Invernizzi, Hazlita Mohd Isa, Shah Md. Islam, Nicholas P. Jones, Deeksha Katoch, Moncef Khairallah, Amit Khosla, Michal Kramer, Amitabh Kumar, Atul Kumar, Rina La Distia Nora, Richard Lee, Careen Y. Lowder, Saurabh Luthra, Padmamalini Mahendradas, Dorine Makhoul, Shahana Mazumdar, Salil Mehta, Elisabetta Miserocchi, Manabu Mochizuki, Oli S. Mohamed, Cristina Muccioli, Marion R. Munk, Somasheila Murthy, Shishir Narain, Heloísa Nascimento, Piergiorgio Neri, Myhanh Nguyen, Annabelle A. Okada, Pınar Özdal, Alan G. Palestine, Francesco Pichi, Sivakumar R. Rathinam, Ariel Schlaen, Shobha Sehgal, H Nida Sen, Aman Sharma, Kusum Sharma, Samir S. Shoughy, Nirbhai Singh, Ramandeep Singh, Masoud Soheilian, Sudharshan Sridharan, Jennifer E. Thorne, Christoph Tappeiner, Stephen C. Teoh, M.S. Tognon, İlknur Tuğal-Tutkun, Mudit Tyagi, Harvey S. Uy
Abstract
An international, expert led consensus initiative was set up by the Collaborative Ocular Tuberculosis Study (COTS) group to develop systematic, evidence, and experience-based recommendations for the treatment of ocular TB using a modified Delphi technique process. In the first round of Delphi, the group identified clinical scenarios pertinent to ocular TB based on five clinical phenotypes (anterior uveitis, intermediate uveitis, choroiditis, retinal vasculitis, and panuveitis). Using an interactive online questionnaires, guided by background knowledge from published literature, 486 consensus statements for initiating ATT were generated and deliberated amongst 81 global uveitis experts. The median score of five was considered reaching consensus for initiating ATT. The median score of four was tabled for deliberation through Delphi round 2 in a face-to-face meeting. This report describes the methodology adopted and followed through the consensus process, which help elucidate the guidelines for initiating ATT in patients with choroidal TB.