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On-tissue amidation of sialic acid with aniline for sensitive imaging of sialylated N-glycans from FFPE tissue sections via MALDI mass spectrometry

Hua Zhang, Xudong Shi, Yuan Liu, Bin Wang, Meng Xu, Nathan V. Welham, Lingjun Li

2022Analytical and Bioanalytical Chemistry16 citationsDOIOpen Access PDF

Topics & Concepts

GlycanChemistryDerivatizationSialic acidMass spectrometry imagingMass spectrometryBiochemistryGlycoproteinAnilineChromatographyOrganic chemistryGlycosylation and Glycoproteins ResearchGenomics and Phylogenetic StudiesRNA and protein synthesis mechanisms
On-tissue amidation of sialic acid with aniline for sensitive imaging of sialylated N-glycans from FFPE tissue sections via MALDI mass spectrometry | Litcius