Simultaneous determination of 13 nitrosamine impurities in biological medicines using salting-out liquid-liquid extraction coupled with liquid chromatography tandem mass spectrometry
Feifei Luo, Yunya Liu, Yang-Guo Xie, Wei Hou, Lei Zhang, Zhongli Zhang
Topics & Concepts
ChemistryChromatographySalting outNitrosamineFormic acidMass spectrometryExtraction (chemistry)Liquid chromatography–mass spectrometryDetection limitTandem mass spectrometryLiquid–liquid extractionAqueous solutionOrganic chemistryCarcinogenWater Treatment and DisinfectionMass Spectrometry Techniques and ApplicationsPolyamine Metabolism and Applications