Polymer-Supported Chiral <i>Cis</i>-Disubstituted Pyrrolidine Catalysts and Their Application to Batch and Continuous-Flow Systems
Hidenori Ochiai, Akira Nishiyama, Naoki Haraguchi, Shinichi Itsuno
Abstract
Polymer-supported cis-pyrrolidine catalysts were developed that allowed for high enantioselectivity and diastereoselectivity compared with those obtained from common trans-pyrrolidine catalysts. Not only configurational but also polymeric effects contribute to the high diastereoselectivity and enantioselectivity. Polymer catalysts were also successfully applied in a continuous-flow process. Acceleration of the reaction rate, an increase in diastereoselectivity, and an improvement in durability were observed in continuous-flow operation compared with the batch system.
Topics & Concepts
PyrrolidineCatalysisContinuous flowPolymerChemistryPolymer chemistryChemical engineeringMaterials scienceOrganic chemistryPhysicsEngineeringMechanicsInnovative Microfluidic and Catalytic Techniques InnovationAsymmetric Hydrogenation and CatalysisAsymmetric Synthesis and Catalysis