Hyper-Synergistic Antifungal Activity of Rapamycin and Peptide-Like Compounds against <i>Candida albicans</i> Orthogonally via Tor1 Kinase
Yaojun Tong, Jingyu Zhang, Luoqiang Wang, Qinqin Wang, Huang Huang, Xiangyin Chen, Qing Zhang, Hantian Li, Nuo Sun, Guang Liu, Buchang Zhang, Fuhang Song, Gil Alterovitz, Huanqin Dai, Lixin Zhang
Abstract
infection in the immunocompromised populations. Instead of prophylactically administering other antifungals with undesirable side-effects for extended durations, we now only need to coadminister some nontoxic peptide additives. The novel antifungal strategy approached in this study not only provides a new therapeutic method to control fungal infections in rapamycin-taking immunocompromised patients but also mitigates the immunosuppressive side-effects of rapamycin, repurposing rapamycin as an antifungal agent with wide applications.
Topics & Concepts
Candida albicansCorpus albicansAntifungal drugFluconazoleDrug repositioningDrugDrug resistanceEffluxPeptideBiologyCalcineurinPharmacologyAntifungalMicrobiologyMedicineBiochemistryTransplantationSurgeryAntifungal resistance and susceptibilitySynthesis and Biological EvaluationPneumocystis jirovecii pneumonia detection and treatment