Litcius/Paper detail

The goal of geroscience is life extension

Mikhail V. Blagosklonny

2021Oncotarget12 citationsDOIOpen Access PDF

Abstract

// Mikhail V. Blagosklonny 1 1 Roswell Park Cancer Institute, Buffalo, NY 14263, USA Correspondence to: Mikhail V. Blagosklonny, email: [email protected] , [email protected] Keywords: aging; longevity; rapamycin; mTOR; metformin Received: December 23, 2020     Accepted: January 13, 2021     Published: February 02, 2021 Copyright: © 2021 Blagosklonny. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ABSTRACT Although numerous drugs seemingly extend healthspan in mice, only a few extend lifespan in mice and only one does it consistently. Some of them, alone or in combination, can be used in humans, without further clinical trials.

Topics & Concepts

LongevityLicenseMedicinePI3K/AKT/mTOR pathwayGerontologyBiologyPolitical scienceGeneticsLawApoptosisGenetics, Aging, and Longevity in Model OrganismsCircadian rhythm and melatoninSpaceflight effects on biology