Temporal analysis of type 1 interferon activation in tumor cells following external beam radiotherapy or targeted radionuclide therapy
Justin C. Jagodinsky, Won Jong Jin, Amber M. Bates, Reinier Hernandez, Joseph J. Grudzinski, Ian R. Marsh, Ishan Chakravarty, Ian S. Arthur, Luke M. Zangl, Ryan Brown, Erin J. Nystuen, Sarah E. Emma, Caroline P. Kerr, Peter M. Carlson, Raghava N. Sriramaneni, Jonathan W. Engle, Eduardo Aluicio‐Sarduy, Todd E. Barnhart, Trаng Lе, KyungMann Kim, Bryan P. Bednarz, Jamey P. Weichert, Ravi B. Patel, Zachary S. Morris
Abstract
We report the time course of the STING-dependent IFN1 response following radiation in multiple murine tumor models. We show the potential of TRT to stimulate IFN1 activation that is comparable to that observed with EBRT and this may be critical to the therapeutic integration of TRT with immunotherapies.
Topics & Concepts
Cancer researchRadiation therapyMedicineIn vivoBlockadeImmune checkpointInterferonImmune systemAgonistImmunotherapyImmunologyInternal medicineBiologyReceptorBiotechnologyCancer Immunotherapy and Biomarkersinterferon and immune responsesNeuroblastoma Research and Treatments