Loss of MFE-2 impairs microglial lipid homeostasis and drives neuroinflammation in Alzheimer’s pathogenesis
Min Gao, Jing Bai, Fangzhou Lou, Yang Sun, Z.H. Wang, Xiaojie Cai, Yan Li, Fengjiao Zhang, Jihuan Liang, Xiangxiao Li, Yue Wu, Ziyang Zhang, Fan Li, Xinping Jin, Honglin Wang
Topics & Concepts
NeuroinflammationMicrogliaProinflammatory cytokineLipid metabolismLipid signalingReactive oxygen speciesInflammationBiologyCell biologyNeurodegenerationArachidonic acidPathogenesisCytokineChemistryImmunologyOxidative stressTumor necrosis factor alphaMitochondrionDruggabilityPhagosomeHomeostasisSignal transductionLipid peroxidationBiochemistryImmune systemEnzymeMetabolic pathwayNeuroprotectionNeuroinflammation and Neurodegeneration MechanismsPeroxisome Proliferator-Activated ReceptorsAlzheimer's disease research and treatments