Ligand-Controlled, Palladium-Catalyzed Asymmetric [4+4] and [2+4] Cycloadditions
Qiuyu Li, Rui Pan, Meihui Wang, Hequan Yao, Aijun Lin
Abstract
)-Cl-MeO-BIPHEP, the chemo- and regioselectivities were switched to synthesize tetrahydropyran-fused spirocyclic compounds in good efficiency via [2+4] cycloaddition reactions.
Topics & Concepts
CycloadditionChemistryLigand (biochemistry)PalladiumCatalysisBenzofuranCombinatorial chemistryTetrahydropyranStereochemistryMedicinal chemistryOrganic chemistryRing (chemistry)ReceptorBiochemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsCyclopropane Reaction Mechanisms