Discovery of a Highly Potent and Selective Dual PROTAC Degrader of CDK12 and CDK13
Jianzhang Yang, Yu Chang, Jean C. Tien, Zhen Wang, Yang Zhou, Pujuan Zhang, Weixue Huang, Josh N. Vo, Ingrid J. Apel, Cynthia Wang, Victoria Zhixuan Zeng, Yunhui Cheng, Shuqin Li, George Xiaoju Wang, Arul M. Chinnaiyan, Ke Ding
Abstract
, suggesting the potential advantage of a CDK12/13 degrader for TNBC targeted therapy.
Topics & Concepts
ChemistryCancer researchProteolysisDNA damageGrowth inhibitionKinaseIn vitroBiologyBiochemistryDNAEnzymeProtein Degradation and InhibitorsAdvanced Breast Cancer TherapiesPARP inhibition in cancer therapy