The association of serum vitamin D level and neonatal respiratory distress syndrome
Weili Liu, Pingping Xu
Abstract
Abstract Background Neonatal respiratory distress syndrome (NRDS) is a critical disease in premature infants. Vitamin D plays an important role in promoting the development of fetal lung structure and the formation of pulmonary surfactants. This study aimed to investigate the correlation between the serum 25(OH)D 3 level in the cord blood of premature infants and the prognosis of NRDS. Methods This retrospective study recruited 82 preterm infants (gestational age 28-36 weeks) diagnosed with NRDS as the NRDS group, and 82 non-NRDS preterm infants as the control group, respectively. The diagnostic efficiency of 25(OH)D 3 on NRDS was revealed by receiver operating characteristics curve (ROC) analysis. Enzyme linked immunosorbent assay (ELISA) was performed to evaluate the 25(OH)D 3 level in the serum of the cord blood in preterm neonates. The NRDS risk indicators were identified by the multivariate logistic regression analysis. Results Cord blood 25(OH)D 3 levels were significantly lower in NRDS preterm infants than control group infants. 25(OH)D 3 levels in cord blood can be used to predict NRDS in preterm infants. In addition, 25(OH)D 3 levels in cord blood were positively correlated with Apgar score (1 min/5 min) and negatively correlated with oxygen support/CPAP duration in preterm infants with NRDS. 25(OH)D 3 in cord blood <57.69 nmol/L (24 ng/ml), gestational age <31 weeks, birth weight <1.86 kg, Apgar score (1 min) <7 and Apgar score (5 min) < 8 were independent risk factors for NRDS. Conclusion 25(OH)D 3 level is an independent risk factor for NRDS in preterm infants.