Biopolymeric Coatings for Local Release of Therapeutics from Biomedical Implants
Sepehr Talebian, Bárbara B. Mendes, João Conniot, Syamak Farajikhah, Fariba Dehghani, Zhong-Yan Li, Diogo B. Bitoque, Gabriela A. Silva, Sina Naficy, João Conde, Gordon G. Wallace
Abstract
The deployment of structures that enable localized release of bioactive molecules can result in more efficacious treatment of disease and better integration of implantable bionic devices. The strategic design of a biopolymeric coating can be used to engineer the optimal release profile depending on the task at hand. As illustrative examples, here advances in delivery of drugs from bone, brain, ocular, and cardiovascular implants are reviewed. These areas are focused to highlight that both hard and soft tissue implants can benefit from controlled localized delivery. The composition of biopolymers used to achieve appropriate delivery to the selected tissue types, and their corresponding outcomes are brought to the fore. To conclude, key factors in designing drug-loaded biopolymeric coatings for biomedical implants are highlighted.