Docosahexaenoic acid lessens hepatic lipid accumulation and inflammation <i>via</i> the AMP-activated protein kinase and endoplasmic reticulum stress signaling pathways in grass carp ( <i>Ctenopharyngodon idella</i> )
Xiaocheng Huang, Jian Sun, Chenchen Bian, Shanghong Ji, Hong Ji
Abstract
. In contrast, the inhibitor of AMPK (compound C, CC) abrogated the effects of DHA to improve PA-induced liver injury and ER stress. In conclusion, DHA inhibits ER stress in hepatocytes by the activation of AMPK and exerts protective effects on hepatic steatosis in terms of improving antioxidant ability, relieving hepatic inflammation and inhibiting hepatic lipogenesis. Our findings give a theoretical foundation for further elucidation of the beneficial role of DHA in vertebrates.
Topics & Concepts
AMPKGrass carpLipogenesisEndocrinologyInternal medicineEndoplasmic reticulumUnfolded protein responseAMP-activated protein kinaseLipid metabolismDocosahexaenoic acidSteatosisInflammationProtein kinase ABiologyChemistryBiochemistryFatty acidKinasePolyunsaturated fatty acidMedicineFisheryFish <Actinopterygii>Adipose Tissue and MetabolismPeroxisome Proliferator-Activated ReceptorsLiver Disease Diagnosis and Treatment