Coumarins from<i>Magydaris pastinacea</i>as inhibitors of the tumour-associated carbonic anhydrases IX and XII: isolation, biological studies and in silico evaluation
Benedetta Fois, Simona Distinto, Rita Meleddu, Serenella Deplano, Elias Maccioni, Costantino Floris, Antonella Rosa, Mariella Nieddu, Pierluigi Caboni, Claudia Sissi, Andrea Angeli, Claudiu T. Supuran, Filippo Cottiglia
Abstract
of 5.7 nM. The cytotoxicity of the most interesting compounds on HeLa cancer cells was also investigated.
Topics & Concepts
Carbonic anhydraseGene isoformHeLaChemistryCoumarinCytotoxicityBiochemistryIsozymeEthyl acetateIn vitroStereochemistryCytosolFurocoumarinsPetroleum etherEnzymeChromatographyGeneOrganic chemistryPhotochemistryExtraction (chemistry)Enzyme function and inhibitionChemical Reactions and MechanismsSynthesis and Biological Evaluation