A cephalosporin–chemiluminescent conjugate increases beta-lactamase detection sensitivity by four orders of magnitude
Santanu Maity, Xiaojian Wang, Subhamoy Das, Maomao He, Lee W. Riley, Niren Murthy
Abstract
The expression of beta-lactamases in bacteria is a central cause of drug resistance. In this report, we present a beta-lactamase chemiluminescent probe, termed CCP, which can for the first time detect beta-lactamase activity via chemiluminescence and can detect beta lactamase with a sensitivity that is 4-orders of magnitude higher than the commercially available fluorescent lactamase substrate fluorocillin.
Topics & Concepts
ChemiluminescenceCephalosporinConjugateChemistryBETA (programming language)Beta-lactamaseSubstrate (aquarium)Sensitivity (control systems)ChromatographyAntibioticsBiologyBiochemistryMathematicsComputer scienceEscherichia coliElectronic engineeringEcologyGeneProgramming languageEngineeringMathematical analysisAntibiotic Resistance in BacteriaBacterial biofilms and quorum sensingAntibiotics Pharmacokinetics and Efficacy