LAG-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T cell NK receptor expression and cytotoxicity
Shin Foong Ngiow, Sasikanth Manne, Yinghui Huang, Tarek Azar, Zeyu Chen, Divij Mathew, Qingzhou Chen, Omar Khan, Jennifer E. Wu, Víctor Alcalde, Ahron Flowers, Symone McClain, Amy E. Baxter, Makoto Kurachi, Junwei Shi, Alexander C. Huang, Josephine R. Giles, Arlene H. Sharpe, Dario A.A. Vignali, E. John Wherry
Topics & Concepts
BiologyCytotoxic T cellCell biologyCD8CytotoxicityLagReceptorGeneticsImmune systemComputer scienceIn vitroComputer networkImmune Cell Function and InteractionCancer Immunotherapy and BiomarkersCAR-T cell therapy research