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LAG-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T cell NK receptor expression and cytotoxicity

Shin Foong Ngiow, Sasikanth Manne, Yinghui Huang, Tarek Azar, Zeyu Chen, Divij Mathew, Qingzhou Chen, Omar Khan, Jennifer E. Wu, Víctor Alcalde, Ahron Flowers, Symone McClain, Amy E. Baxter, Makoto Kurachi, Junwei Shi, Alexander C. Huang, Josephine R. Giles, Arlene H. Sharpe, Dario A.A. Vignali, E. John Wherry

2024Cell98 citationsDOIOpen Access PDF

Topics & Concepts

BiologyCytotoxic T cellCell biologyCD8CytotoxicityLagReceptorGeneticsImmune systemComputer scienceIn vitroComputer networkImmune Cell Function and InteractionCancer Immunotherapy and BiomarkersCAR-T cell therapy research
LAG-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T cell NK receptor expression and cytotoxicity | Litcius