Obacunone protects retinal pigment epithelium cells from ultra-violet radiation-induced oxidative injury
Darui Huang, Changming Dai, Shuyan Li, Xiaofeng Li
Abstract
, intravitreal injection of obacunone largely inhibited light-induced retinal damage. Collectively, obacunone protects RPE cells from UVR-induced oxidative injury through activation of Nrf2 signaling cascade.
Topics & Concepts
Retinal pigment epitheliumCell biologyPigmentEpitheliumOxidative phosphorylationChemistryRetinalBiologyPathologyMedicineBiochemistryOrganic chemistryRetinal Diseases and TreatmentsRetinal Development and Disordersmelanin and skin pigmentation