Developing Integrated Approaches for Testing and Assessment (IATAs) in order to support nanomaterial safety
Leagh Powell, Suzanne Gillies, Teresa F. Fernandes, Fiona Murphy, Elisa Giubilato, Virginia Cazzagon, Danail Hristozov, Lisa Pizzol, Magda Blosi, Anna Luisa Costa, Adriele Prina‐Mello, Hans Bouwmeester, Haralambos Sarimveis, Gemma Janer, Vicki Stone
Abstract
model predictions where available and appropriate, and/or experimental procedures and protocols for generating new data to fill gaps. This allows NM developers to work toward current guidelines and regulations, while taking NM specific considerations into account. Here, an example IATA for NMs with potential for direct blood contact was developed for the assessment of haemocompatibility. This example IATA brings together the current guidelines for NM safety assessment within a framework that can be used to guide information and data gathering for the safety assessment of intravenously injected NMs. Additionally, the decision framework underpinning this IATA has the potential to be adapted to other testing needs and regulatory contexts.