Discovery of novel hybrids of mTOR inhibitor and NO donor as potential anti-tumor therapeutics
Xin Gao, Fang Zhao, Yang Wang, Xiaodong Ma, Hua-Yi Chai, Jingjing Han, Fang Fang
Topics & Concepts
ChemistryPI3K/AKT/mTOR pathwayIC50Discovery and development of mTOR inhibitorsmTORC1Protein kinase BKinasePharmacologyCytotoxicityIn vitroBiochemistrySignal transductionBiologyPI3K/AKT/mTOR signaling in cancerClick Chemistry and ApplicationsEnzyme function and inhibition