Enhanced virulence and waning vaccine-elicited antibodies account for breakthrough infections caused by SARS-CoV-2 delta and beyond
Hyung‐Joon Kwon, Martina Košíková, Weichun Tang, Uriel Ortega‐Rodriguez, Peter Radvák, Ruoxuan Xiang, Kelly E. Mercer, Levan Muskhelishvili, Kelly Cue Davis, Jerrold M. Ward, Ivan Košík, Jaroslav Hollý, Insung Kang, Jonathan W. Yewdell, Ewan P. Plant, Wilbur H. Chen, Mallory Shriver, Robin S. Barnes, Marcela F. Pasetti, Bin Zhou, David E. Wentworth, Hang Xie
Abstract
, the mean log neutralization titers against the latest Omicron subvariants are 1/3-1/2 of those against the original 614D virus. Our results suggest that enhanced virulence, greater immune evasion, and waning of vaccine-elicited protection account for SARS-CoV-2 variants caused breakthrough infections.
Topics & Concepts
VaccinationVirologyNeutralizing antibodyNeutralizationVirusAntibodyVirulenceBiologyImmune systemTiterIn vivoImmunologyAttenuated vaccinePneumoniaMedicineGeneInternal medicineBiochemistryBiotechnologySARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesAnimal Virus Infections Studies