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Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide

Eric S. Fischer, Kerstin Böhm, John R. Lydeard, Haidi Yang, Michael Stadler, Simone Cavadini, Jane Nagel, Fabrizio C. Serluca, Vincent Acker, Gondichatnahalli M. Lingaraju, Ritesh B. Tichkule, Michael Schebesta, William C. Forrester, Markus Schirle, Ulrich Hassiepen, Johannes Ottl, Marc Hild, Rohan E. J. Beckwith, J. Wade Harper, Jeremy L. Jenkins, Nicolas H. Thomä

2014Nature1,095 citationsDOIOpen Access PDF

Topics & Concepts

CereblonUbiquitin ligaseThalidomidePomalidomideUbiquitin-Protein LigasesDDB1UbiquitinTranscription factorCancer researchLenalidomideCell biologyChemistryBiologyMultiple myelomaGeneticsImmunologyGeneProtein Degradation and InhibitorsMultiple Myeloma Research and TreatmentsUbiquitin and proteasome pathways
Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide | Litcius