Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide
Eric S. Fischer, Kerstin Böhm, John R. Lydeard, Haidi Yang, Michael Stadler, Simone Cavadini, Jane Nagel, Fabrizio C. Serluca, Vincent Acker, Gondichatnahalli M. Lingaraju, Ritesh B. Tichkule, Michael Schebesta, William C. Forrester, Markus Schirle, Ulrich Hassiepen, Johannes Ottl, Marc Hild, Rohan E. J. Beckwith, J. Wade Harper, Jeremy L. Jenkins, Nicolas H. Thomä
Topics & Concepts
CereblonUbiquitin ligaseThalidomidePomalidomideUbiquitin-Protein LigasesDDB1UbiquitinTranscription factorCancer researchLenalidomideCell biologyChemistryBiologyMultiple myelomaGeneticsImmunologyGeneProtein Degradation and InhibitorsMultiple Myeloma Research and TreatmentsUbiquitin and proteasome pathways