Palladium-catalyzed carbonylative synthesis of acrylamides from alkenyl thianthrenium salts
A Ru‐Han, Jiajun Zhang, Xiao‐Feng Wu
Abstract
-aryl acrylamides in high yields (>90%) with excellent chemoselectivity and functional group tolerance. Furthermore, the method is readily scalable to the gram level without compromising efficiency. This work demonstrates the synthetic potential of vinyl thianthrenium salts in carbonylation chemistry and offers a general, robust, and scalable approach for the preparation of functionalized acrylamides under mild conditions.
Topics & Concepts
ChemoselectivityCarbonylationChemistryElectrophileOrganic chemistryCombinatorial chemistryCatalysisAcrylamideOrganic synthesisEpoxideReaction conditionsCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques