Mitochondrial transfer drives immune evasion in tumor microenvironment
Qiang Cai, Xiaojun Cai, Quazi T.H. Shubhra
Abstract
Tumors subvert T cell metabolism through diverse mechanisms. Ikeda et al. reveal mitochondrial transfer as a tumor-driven immune evasion strategy, where cancer cells deliver dysfunctional mitochondria to T cells, impairing metabolism and inducing exhaustion. These findings highlight mitochondrial dynamics as a promising therapeutic target to improve immunotherapy outcomes.
Topics & Concepts
Evasion (ethics)Immune systemTumor microenvironmentGene transferCell biologyBiologyMitochondrionChemistryImmunologyBiochemistryGeneImmune cells in cancerCancer, Hypoxia, and MetabolismFerroptosis and cancer prognosis