Comparison of Agar Dilution to Broth Microdilution for Testing <i>In Vitro</i> Activity of Cefiderocol against Gram-Negative Bacilli
Mariana Albano, Melissa J. Karau, Audrey N. Schuetz, Robin Patel
Abstract
Cefiderocol (CFDC) is a siderophore cephalosporin with activity against Gram-negative bacterial species that are resistant to carbapenems and other drugs. The MICs of CFDC were determined for 610 Gram-negative bacilli, including 302 multinational Enterobacterales isolates with characterized mechanisms of beta-lactam resistance, 180 clinical isolates from the Mayo Clinic and Mayo Clinic Laboratories not characterized for specific resistance mechanisms, and 128 isolates with CFDC MICs of ≥8 μg/ml obtained from International Health Management Associates, Inc.
Topics & Concepts
BacilliMicrobiologyCephalosporinAgar dilutionBroth microdilutionSiderophoreBiologyGramAgarBacteriaMinimum inhibitory concentrationAntibioticsGeneticsAntibiotic Resistance in BacteriaAntibiotics Pharmacokinetics and EfficacyInfections and bacterial resistance