Weak Coordination Enabled Switchable C4-Alkenylation and Alkylation of Indoles with Allyl Alcohols
Sourav Pradhan, Manmath Mishra, Pinaki Bhusan De, Sonbidya Banerjee, Tharmalingam Punniyamurthy
Abstract
A weak carbonyl coordination facilitated tunable reactivity between alkenylation and alkylation of indoles at the C4 C-H site is presented using readily accessible allylic alcohols in the presence of Rh catalysis by switching the additives or directing group. Exclusive site selectivity, functional group tolerance, and late-stage modifications are the important practical features.
Topics & Concepts
ChemistryAlkylationOrganic chemistryAllyl alcoholCombinatorial chemistryMedicinal chemistryCatalysisCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and CatalysisCatalytic Cross-Coupling Reactions