Calcium Channel Blocker Nifedipine Suppresses Colorectal Cancer Progression and Immune Escape by Preventing NFAT2 Nuclear Translocation
Ling Wu, Weihao Lin, Qing Liao, Hui Wang, Chuang Lin, Lihua Tang, Weidong Lian, Zetao Chen, Kaitao Li, Lijun Xu, Rui Zhou, Yanqing Ding, Liang Zhao
Abstract
T cells and reactivates tumor immune monitoring, which may stimulate or enhance PD-1-based antitumor immunotherapy. Our findings provide direct evidence that NIFE is a promising clinical therapy to treat patients with advanced CRC by affecting the tumor itself and tumor immunity. NIFE may be a promising therapeutic option to enhance effectiveness of immune checkpoint blockade therapy in CRC.
Topics & Concepts
Calcium channel blockerCancer researchNifedipineColorectal cancerImmune systemTumor progressionImmune checkpointImmunotherapyCalcium channelMetastasisMedicineCancerCalciumPharmacologyImmunologyInternal medicineSignaling Pathways in DiseaseIon Channels and ReceptorsPharmacological Receptor Mechanisms and Effects