Emergence of Canonical and Noncanonical Genomic Variants following <i>In Vitro</i> Exposure of Clinical Mycobacterium tuberculosis Strains to Bedaquiline or Clofazimine
Nabila Ismail, Anzaan Dippenaar, Robin M. Warren, Remco P. H. Peters, Shaheed Vally Omar
Abstract
In Mycobacterium tuberculosis , bedaquiline and clofazimine resistance occurs primarily through Rv0678 variants, a gene encoding a repressor protein that regulates mmpS5 / mmpL5 efflux pump gene expression. Despite the shared effect of both drugs on efflux, little else is known about other pathways affected.
Topics & Concepts
ClofazimineBedaquilineEffluxMycobacterium tuberculosisTetRBiologyTuberculosisGeneRepressorMicrobiologyIn vitroMycobacterium lepraeGeneticsGene expressionMedicineImmunologyLeprosyPathologyTuberculosis Research and EpidemiologyMycobacterium research and diagnosisPneumocystis jirovecii pneumonia detection and treatment