Electrochemical Trifluoromethylation and Sulfonylation of <i>N</i>-Allylamides: Synthesis of Oxazoline Derivatives
Shujun Chen, Weiqiang Zhong, Jing‐Mei Huang
Abstract
We report a new method for the synthesis of trifluoromethylated and sulfonylated oxazolines by electrochemical radical cascade cyclizations of N -allylamides with sodium trifluoromethanesulfinate or sulfonylhydrazines. This protocol provides a green and useful strategy to synthesize trifluoromethylated and sulfonylated oxazolines with a broad substrate scope under ambient conditions.
Topics & Concepts
ChemistryOxazolineTrifluoromethylationCombinatorial chemistryElectrochemistrySubstrate (aquarium)CascadeScope (computer science)Organic chemistryChromatographyCatalysisTrifluoromethylComputer sciencePhysical chemistryElectrodeProgramming languageGeologyOceanographyAlkylSulfur-Based Synthesis TechniquesFluorine in Organic ChemistryRadical Photochemical Reactions