Copper-Catalyzed Dynamic Kinetic Resolution of Secondary Phosphine Oxides
Baixue Liu, Peng Liu, Xue Wang, Feng Feng, Zhen Wang, Wenqiang Yang
Abstract
Copper-catalyzed dynamic kinetic resolution of secondary phosphine oxides has been successfully developed, providing a general method for the gram-scale enantioselective synthesis of P -stereogenic cyclic phosphine oxides with high yields and high enantioselectivities. The products could be easily reduced to the corresponding useful P (III)-stereogenic cyclic phosphines. A mechanism of the dynamic kinetic resolution involving the unusual rapid racemization of SPOs has been proposed.
Topics & Concepts
StereocenterPhosphineKinetic resolutionChemistryRacemizationCopperCatalysisEnantioselective synthesisKinetic energyResolution (logic)Combinatorial chemistryOrganic chemistryComputer sciencePhysicsQuantum mechanicsArtificial intelligenceAsymmetric Hydrogenation and CatalysisAsymmetric Synthesis and CatalysisSynthetic Organic Chemistry Methods