First-in-class small molecule inhibitors of ICOS/ICOSL interaction as a novel class of immunomodulators
Somaya A. Abdel‐Rahman, Katarzyna Świderek, Moustafa T. Gabr
Abstract
revealed a dose-dependent ability to block ICOS/ICOSL interaction in a bioluminescent cellular assay based on co-culturing Jurkat T cells expressing ICOS and CHO-K1 cells expressing ICOSL. This work will pave the way for future drug discovery efforts aiming at the development of small molecule inhibitors of ICOS/ICOSL interaction as potential therapeutics for cancer as well as other diseases.
Topics & Concepts
Förster resonance energy transferMonoclonal antibodyChemistryJurkat cellsIC50CellCell biologyAntibodyFluorescenceBiophysicsT cellMolecular biologyBiochemistryIn vitroBiologyImmunologyPhysicsImmune systemQuantum mechanicsReceptor Mechanisms and SignalingNeuroinflammation and Neurodegeneration MechanismsNeutrophil, Myeloperoxidase and Oxidative Mechanisms