Development of de-novo coronavirus 3-chymotrypsin-like protease (3CLpro) inhibitors since COVID-19 outbreak: A strategy to tackle challenges of persistent virus infection
Lei Tian, Taotao Qiang, Xiuding Yang, Gao Yue, Xiaopei Zhai, Kairui Kang, Cong Du, Qi Lü, Hong Gao, Dezhu Zhang, Xiaolin Xie, Chengyuan Liang
Topics & Concepts
PeptidomimeticVirologyProteaseCoronavirus disease 2019 (COVID-19)Drug developmentOutbreakCoronavirusChemistryAntiviral drugSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Computational biologyPharmacologyVirusDrugBiologyEnzymeMedicineBiochemistryInfectious disease (medical specialty)DiseasePeptidePathologyProtein Degradation and InhibitorsPeptidase Inhibition and AnalysisUbiquitin and proteasome pathways