Mediator-free electrochemical trifluoromethylation: a cascade approach for the synthesis of trifluoromethylated isoxazolines
Kingshuk Mahanty, Suman Kumar Saha, Atreyee Halder, Suman De Sarkar
Abstract
-radical generation, followed by cascade cyclization fabricating an isoxazoline scaffold from a β,γ-unsaturated oxime. Consecutive C-O and C-C bond formations were achieved through this method featuring mild, robust, and scalable reaction conditions and broad substrate scope. Mechanistic studies revealed the necessity of anodic oxidation for the cascade process. Further conversion of the isoxazoline afforded other valuable derivatives.
Topics & Concepts
TrifluoromethylationCascadeChemistryCombinatorial chemistrySubstrate (aquarium)ElectrochemistryAnodeOximeOrganic chemistryTrifluoromethylElectrodeOceanographyPhysical chemistryGeologyAlkylChromatographyFluorine in Organic ChemistryRadical Photochemical ReactionsCO2 Reduction Techniques and Catalysts