Adipose-Secreted Exosomes and Their Pathophysiologic Effects on Skeletal Muscle
Binglin Yue, Hui Wang, Xin Cai, Jiabo Wang, Zhixin Chai, Wei Peng, Shi Shu, Changqi Fu, Jincheng Zhong
Abstract
Due to its prominent secretory activity, adipose tissue (AT) is now considered a major player in the crosstalk between organs, especially with skeletal muscle. In which, exosomes are effective carriers for the intercellular material transfer of a wide range of molecules that can influence a series of physiological and pathological processes in recipient cells. Considering their underlying roles, the regulatory mechanisms of adipose-secreted exosomes and their cellular crosstalk with skeletal muscle have received great attention in the field. In this review, we describe what is currently known of adipose-secreted exosomes, as well as their applications in skeletal muscle pathophysiology.