Modulating active targeting nanoparticle design according to tumor progressions
Huifang Nie, Rong Huang, Guangwei Jiang, Wenshuai Li, Lan Yang, Meng Zhang, Min Qian, Wei Guo, Tao Ye, Rongqin Huang
Abstract
. In the midterm, tumor accumulation of active AuNPs was equally influenced by size effects and multivalent interactions. Therefore, RGD-modified nanoparticles with sizes of 7 and 90 nm accumulated more in tumors. This study will guide a rational design of active targeting nanoparticles for enhancing the diagnosis and treatment of tumors based on their progressions.
Topics & Concepts
NanoparticleComputer scienceNanotechnologyChemistryMaterials scienceNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranosticsRNA Interference and Gene Delivery