Severe acute pancreatitis: capillary permeability model linking systemic inflammation to multiorgan failure
Nicole Komara, Pedram Paragomi, Phil J. Greer, Annette Wilson, Cameron R. Breze, Georgios I. Papachristou, David C. Whitcomb
2020American Journal of Physiology-Gastrointestinal and Liver Physiology94 citationsDOIOpen Access PDF
Abstract
Acute pancreatitis is a sudden inflammatory response to pancreatic injury that may spread to systemic inflammation, multiorgan failure, and death in some patients. With the use of the predictions of a new mechanistic model, we compared patients with severe acute pancreatitis with or without multiorgan failure. All biomarkers of capillary leak and clinical features of multiorgan failure were accurately predicted. This provides a new paradigm for understanding and developing new treatments for patients with severe acute pancreatitis.
Topics & Concepts
Acute pancreatitisMultiorgan failureMedicineSystemic inflammatory response syndromePancreatitisSystemic inflammationInflammationInternal medicineIntensive care medicineSepsisPancreatitis Pathology and TreatmentPancreatic and Hepatic Oncology ResearchSepsis Diagnosis and Treatment