All‐in‐One Self‐Powered Microneedle Device for Accelerating Infected Diabetic Wound Repair
Weikun Li, Zonghao Liu, Xin Tan, Ning Yang, Yanling Liang, Diyi Feng, Han Li, Renqiang Yuan, Qianli Zhang, Ling Liu, Liqin Ge
Abstract
Abstract Diabetic wound healing remains a significant clinical challenge due to the complex microenvironment and attenuated endogenous electric field. Herein, a novel all‐in‐one self‐powered microneedle device (termed TZ@mMN‐TENG) is developed by combining the multifunctional microneedle carried tannin@ZnO microparticles (TZ@mMN) with the self‐powered triboelectric nanogenerator (TENG). In addition to the delivery of tannin and Zn 2+ , TZ@mMN also effectively conducts electrical stimulation (ES) to infected diabetic wounds. As a self‐powered device, the TENG can convert biomechanical motion into exogenous ES to accelerate the infected diabetic wound healing. In vitro experiment demonstrated that TZ@mMN shows excellent conductive, high antioxidant ability, and effective antibacterial properties against both Staphylococcus aureus and Escherichia coli (>99% antibacterial rates). Besides, the TZ@mMN‐TENG can effectively promote cell proliferation and migration. In the diabetic rat full‐thickness skin wound model infected with Staphylococcus aureus , the TZ@mMN‐TENG can eliminate bacteria, accelerate epidermal growth (regenerative epidermis: ≈303.3 ± 19.1 µm), enhance collagen deposition, inhibit inflammation (lower TNF‐α and IL‐6 expression), and promote angiogenesis (higher CD31 and VEGF expression) to accelerate infected wound repair. Overall, the TZ@mMN‐TENG provides a promising strategy for clinical application in diabetic wound repair.