Noncoding RNA transcription alters chromosomal topology to promote isotype-specific class switch recombination
Gerson Rothschild, Wanwei Zhang, Junghyun Lim, Pankaj K. Giri, Brice Laffleur, Yiyun Chen, Mingyan Fang, Yuling Chen, Lekha Nair, Zhi‐Ping Liu, Haiteng Deng, Lennart Hammarström, Jiguang Wang, Uttiya Basu
Abstract
A noncoding RNA–expressing element drives IgA class switch recombination.
Topics & Concepts
BiologyImmunoglobulin class switchingEnhancerCytidine deaminaseSomatic hypermutationGeneticsPromoterTranscription (linguistics)RNAGeneTranscription factorMolecular biologyB cellAntibodyGene expressionPhilosophyLinguisticsT-cell and B-cell ImmunologyImmune Cell Function and InteractionCancer-related molecular mechanisms research