NaOH-Mediated Direct Synthesis of Quinoxalines from <i>o</i>-Nitroanilines and Alcohols via a Hydrogen-Transfer Strategy
Yanbing Wang, Linlin Shi, Xiaojie Zhang, Lian-Rong Fu, Weinan Hu, Wenjing Zhang, Xinju Zhu, Xin‐Qi Hao, Mao‐Ping Song
Abstract
A NaOH-mediated sustainable synthesis of functionalized quinoxalines is disclosed via redox condensation of o-nitroamines with diols and α-hydroxy ketones. Under optimized conditions, various o-nitroamines and alcohols are well tolerated to generate the desired products in 44–99% yields without transition metals and external redox additives.
Topics & Concepts
RedoxChemistryCondensationOrganic chemistryCombinatorial chemistryThermodynamicsPhysicsSynthesis and Biological EvaluationNanomaterials for catalytic reactionsAsymmetric Hydrogenation and Catalysis