NMDA receptor-dependent prostaglandin-endoperoxide synthase 2 induction in neurons promotes glial proliferation during brain development and injury
Jia Zhou, Yang Geng, Tonghui Su, Qiuyan Wang, Yongfei Ren, Jing Zhao, Chaoying Fu, Martin Weber, Han Lin, Joshua S. Kaminker, Nan Liu, Morgan Sheng, Yelin Chen
Abstract
). NMDAR inhibition or Ptgs2 genetic ablation in mice reduced the proliferation of astrocytes and microglia induced by mild traumatic brain injury in the absence of secondary excitotoxicity-induced neuronal death. Our study defines an NMDAR-mediated signaling mechanism that allows trans-cellular control of glial proliferation by neurons in brain development and injury.
Topics & Concepts
AstrocyteNMDA receptorCell biologyExcitotoxicityMicrogliaBiologyNeuroscienceCell growthNeurogliaHippocampal formationReceptorChemistryCentral nervous systemImmunologyBiochemistryInflammationNeuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology ResearchS100 Proteins and Annexins