Design, synthesis and evaluation of ursodeoxycholic acid-cinnamic acid hybrids as potential anti-inflammatory agents by inhibiting Akt/NF-κB and MAPK signaling pathways
Xiaoxue Li, Yue Hu, Bing-xin He, Lingyu Li, Yu Tian, Yingjie Xiao, Hai Shang, Zhong‐Mei Zou
Topics & Concepts
ChemistryProtein kinase BUrsodeoxycholic acidMAPK/ERK pathwayNF-κBPharmacologyCinnamic acidNitric oxideAnti-inflammatoryIn vivoInflammationSignal transductionBiochemistryImmunologyBiologyBiotechnologyOrganic chemistryGenomics, phytochemicals, and oxidative stressInflammatory mediators and NSAID effectsBioactive Compounds and Antitumor Agents