Deciphering the Proteomic Landscape of <i>Mycobacterium tuberculosis</i> in Response to Acid and Oxidative Stresses
Eira Choudhary, Rishabh Sharma, Pramila Pal, Nisheeth Agarwal
Abstract
-treated bacilli. Overall, we delineated the adaptive mechanisms that Mtb may utilize under physiological stresses and possible overlap between the responses to these stress conditions. In addition to offering important protein signatures that can be exploited for future mechanistic studies, our study highlights the importance of proteomics in understanding complex adjustments made by the human pathogen during infection.
Topics & Concepts
ProteomeMycobacterium tuberculosisProteomicsBiologyMechanism (biology)MetabolomicsPathogenTuberculosisBacteriaCell biologyOxidative stressMicrobiologyComputational biologyOxidative phosphorylationMetabolic pathwayBiochemistryBioinformaticsMetabolismGeneticsGenePathologyPhilosophyEpistemologyMedicineTuberculosis Research and EpidemiologyAntibiotic Resistance in BacteriaBiochemical and Molecular Research