Copper release by MOF-74(Cu): a novel pharmacological alternative to diseases with deficiency of a vital oligoelement
Javier Águila-Rosas, Betzabeth A. García-Martínez, Camilo Rı́os, Araceli Dı́az-Ruiz, Juan L. Obeso, Carlos Tomás Quirino-Barreda, Ilich A. Ibarra, Ariel Guzmán‐Vargas, Enrique Lima
Abstract
after oral administration in male Wistar rats. Taking advantage of the abundance and high periodicity of copper within the crystalline-nanostructured metal-organic framework material (MOF-74(Cu)), it was possible to control the release of copper due to the partial degradation of the material. Thus, we simultaneously corroborated a low accumulation of copper in the liver (the main detoxification organ) and a slight increase of copper in the brain (striatum and midbrain), demonstrating that MOF-74(Cu) is a promising pharmacological alternative (controlled copper source) to these diseases.