Discovery of novel 7,8-dihydropteridine-6(5H)-one-based DNA-PK inhibitors as potential anticancer agents via scaffold hopping strategy
Zongbao Ding, Wei Pan, Yao Xiao, Binbin Cheng, Gang Huang, Jianjun Chen
Topics & Concepts
ChemistryDruggabilityIn vivoIC50PharmacologyDoxorubicinDNAIn vitroBiochemistryBiologyChemotherapyGeneGeneticsBiotechnologyCancer therapeutics and mechanismsAdvanced biosensing and bioanalysis techniquesDNA and Nucleic Acid Chemistry