Multicomponent Synthesis of <i>S</i>-Benzyl Dithiocarbamates from <i>para</i>-Quinone Methides and Their Biological Evaluation for the Treatment of Alzheimer’s Disease
Rapelly Venkatesh, Gauri Shankar, Aswathi C. Narayanan, Gyan Modi, Shahulhameed Sabiah, Jeyakumar Kandasamy
Abstract
Multicomponent synthesis of biologically relevant S-benzyl dithiocarbamates from para-quinone methides, amines, and carbon disulfide are described under catalyst and additive-free conditions. The reactions proceeded at room temperature in a short span of time with excellent yields. One of the synthesized compounds, 3e showed considerable acetylcholinesterase (AChE) inhibitory (51.70 + 5.63% at 20 μm) and antioxidant (63.52 ± 1.15 at 20 μm) activities.
Topics & Concepts
AcetylcholinesteraseQuinoneAntioxidantChemistryCatalysisBiological activityOrganic chemistryCombinatorial chemistryEnzymeBiochemistryIn vitroSynthesis of Indole DerivativesSulfur-Based Synthesis TechniquesChemical Synthesis and Reactions