No Effect of Lactobacillus rhamnosus GG on Eradication of Colonization by Vancomycin-Resistant Enterococcus faecium or Microbiome Diversity in Hospitalized Adult Patients
Ingrid Maria Cecilia Rubin, Sarah Mollerup, Christa Broholm, Signe Boye Knudsen, Adam Baker, Morten Helms, Mona Katrine Alberthe Holm, Thomas Kallemose, Henrik Westh, Jenny Dahl Knudsen, Mette Pinholt, Andreas Munk Petersen
Abstract
Whereas other studies exploring the effect of L. rhamnosus in clearing VREfm from the intestine included children and adults, with a wider age range, our study consisted of a geriatric patient cohort. The natural clearance of VREfm in this study was almost 60% after 4 weeks, thus much higher than described previously. Also, this study characterizes the microbiome of VREfm patients in detail. This article showed no effect of the probiotic L. rhamnosus in clearing VREfm from the intestine of patients.
Topics & Concepts
Lactobacillus rhamnosusPlaceboMedicineEnterococcus faeciumInternal medicineDiscontinuationFecesColonizationRandomized controlled trialCarriageEnterococcusProbioticLactobacillus reuteriGastroenterologyAntibioticsBiologyMicrobiologyBacteriaAlternative medicinePathologyGeneticsProbiotics and Fermented FoodsClostridium difficile and Clostridium perfringens researchGut microbiota and health