Determination of protein conformation and orientation at buried solid/liquid interfaces
Wen Guo, Tieyi Lu, Ralph Crisci, Satoshi Nagao, Tao Wei, Zhan Chen
Abstract
A systematic method combining SFG vibrational spectroscopy, isotope labeling, spectra calculation and computer simulation was developed to elucidate interfacial structures of proteins.
Topics & Concepts
In situSum frequency generation spectroscopyInterface (matter)Orientation (vector space)CrystallographyChemical physicsChemistryPolymerMolecular dynamicsMaterials scienceMoleculeSum-frequency generationComputational chemistryNonlinear systemOrganic chemistryPhysicsNonlinear opticsGeometryGibbs isothermMathematicsQuantum mechanicsSpectroscopy and Quantum Chemical StudiesChemical and Physical Properties in Aqueous SolutionsPhotosynthetic Processes and Mechanisms