Copper-catalyzed regioselective 1,4-sulfonylcyanation of 1,3-enynes with sulfonyl chlorides and TMSCN
Yunhe Lv, Wanru Han, Weiya Pu, Jinhui Xie, Axue Wang, Mengyue Zhang, Jin Wang, Junrong Lai
Abstract
A novel and practical copper-catalyzed 1,4-sulfonylcyanation of 1,3-enynes with sulfonyl chlorides and TMSCN has been developed under mild conditions.
Topics & Concepts
ChemistrySulfonylRegioselectivityCatalysisCopperMedicinal chemistryOrganic chemistryCombinatorial chemistryAlkylSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization MethodsChemical Synthesis and Reactions