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Structure-based design, drug-likeness, and pharmacokinetic studies of novel substituted pyrimidine derivatives as potent HCV NS3/A4 protease inhibitors

Stephen Ejeh, Adamu Uzairu, Gideon Adamu Shallangwa, Stephen Eyije Abechi, Muhammad Tukur Ibrahim

2022Biocatalysis and Agricultural Biotechnology11 citationsDOI

Topics & Concepts

In silicoNS3PubChemProteaseHepatitis C virusDrugDruggabilityPharmacologyPopulationDrug discoveryChemistrySmall moleculeProtease inhibitor (pharmacology)VirologyEnzymeComputational biologyMedicineBiologyHuman immunodeficiency virus (HIV)BiochemistryVirusViral loadAntiretroviral therapyGeneEnvironmental healthHepatitis C virus researchComputational Drug Discovery MethodsHIV/AIDS drug development and treatment
Structure-based design, drug-likeness, and pharmacokinetic studies of novel substituted pyrimidine derivatives as potent HCV NS3/A4 protease inhibitors | Litcius