Potential acridinedione derivatives for the development of a heterobifunctional PROTAC for targeted degradation of PCSK9 protein
Vijay Kumar Bhardwaj, Rituraj Purohit
Topics & Concepts
Allosteric regulationChemistryProprotein convertaseMoleculePCSK9Docking (animal)Small moleculeKexinBiophysicsLDL receptorBiochemistryReceptorLipoproteinMedicineCholesterolBiologyOrganic chemistryNursingProtein Degradation and InhibitorsPeptidase Inhibition and AnalysisUbiquitin and proteasome pathways