Synthesis of Indolo[2,1‐a]isoquinolin‐6(5H)‐Ones Derivatives <i>via</i> Fe(OTf)<sub>3</sub>‐Promoted Tandem Selenylation/Cyclization of 2‐Arylindoles
Jia‐Rong Zhang, Haoyang Liu, Tao Fan, Yanyan Chen, Yanli Xü
Abstract
Abstract A practical method for the synthesis of selenylsubstituted indolo[2,1‐ a ]isoquinolin‐6(5 H )‐ones through Fe(OTf) 3 ‐promoted tandem selenylation/cyclization of 2‐arylindoles was developed. In this transformation, new C−Se bond and C−C bond were constructed simultaneously under mild conditions. magnified image
Topics & Concepts
ChemistryTandemTransformation (genetics)Combinatorial chemistryMedicinal chemistryComputational chemistryStereochemistryMaterials scienceBiochemistryGeneComposite materialCatalytic C–H Functionalization MethodsSulfur-Based Synthesis TechniquesSynthesis of Indole Derivatives